Monday, December 24, 2007
Merry Christmas!
Hope you have a great time over the festive period.
Drive carefully, stay safe and see you after Boxing Day...
Friday, December 14, 2007
What is Dutasteride? (part two)
Dutasteride is a dual DHT inhibitor, meaning that it acts on both type I and type II of the enzyme 5-alpha-reductase. Results have shown that its use can lead to a 93% reduction in the conversion of testosterone into DHT in the body, much higher than the inhibiting ability of Finasteride. It is possible that executives at GlaxoSmithKline were uneasy about the fact that because their DHT inhibitor was more powerful than Finasteride, despite the fact that this led to increased benefits as far as hair loss were concerned, the drug might be too strong for a nervous market in which Finasteride was already underperforming.
Although not confirmed, the final phase of Dutasteride testing may once again be underway. In the meantime it has begun to be prescribed off-label for some men hoping that its powers to inhibit DHT will help them retain or grow back more of their hair than Finasteride is capable of achieving for them. Because its side effects may be more severe and neither the dosage nor the long term impact of the drug for the purposes of hair loss have been approved by the FDA however, there are many reasons to be wary about the use of Dutasteride in this way.
Still, this could be the next systemic drug to be approved by the FDA to treat hair loss. If you are impatient and willing to take the risk, a 0.5 mg soft gel will currently cost you $2-3 per dose with a prescription. Beware however that it is not possible to easily divide a soft gel capsule into smaller quantities the way Finasteride users have been able to cut up larger doses of Proscar originally intended to treat BPH. Also, considering the fact that studies have shown that Dutasteride remains in the body for up to 240 hours (as opposed to 6-8 for Finasteride) after being taken, and that in some cases DHT was at only 25% of its normal levels up to a year after ceasing to take the drug, you might want to think seriously about those uncharted side effects. As with Finasteride, Dutasteride should never be handled by women who are pregnant or may become pregnant.
Monday, December 10, 2007
What is Dutasteride? (part one)
In a repeat of the history of Finasteride's development as a hair loss drug, GlaxoSmithKline set about conducting trials into the use of Dutasteride, their own DHT inhibitor, for the same purposes. However, the company shelved their plans for a drug to rival Finasteride in the market for hair loss treatments after phase 2 trials of Dutasteride had been completed. It is not clear why they didn't go through with a final phase of testing the drug in preparation for its approval as a hair loss treatment but it has been speculated that market forces were responsible. The company had been going through a number of mergers which may have had an impact on continuity in decision making among their various divisions. In addition to this, Finasteride, while already established on the market as an effective hair loss treatment, had not been meeting Wall Street's profit expectations. This may have been due to negative publicity surrounding the potential side effects of the drug as far as sex drive and sexual performance were concerned...
More tomorrow.
Monday, December 03, 2007
Hair loss forums
Hair Loss Talk and Hair Loss Help
I've registered at both and am looking forward to meeting the regulars, I hope they're friendly!
PS I'll add a link to these site here on the blog but also over in the links section of my main site, if anyone has any other recommendations for great hair loss sites to link to please let me know!
Friday, November 30, 2007
The big bald question: Which hat to wear while jogging?
The solution, naturally, is to go jogging, and that's exactly what I'm going to do (as often as possible between now and when the leaves start to grow back on the trees). The problem caused by this solution is that I'm even more self aware of being bald when I'm running than when I'm just walking around trying to mind my own business. No doubt Richard Dawkins would say that's because people have developed to pay attention to moving objects, I'd say it's because they like to point and laugh at shiny things. Anyway, the way round this is obviously to wear a hat, but which one? Having a had a quick look in the cupboard my choices are as follows:
- A fluffy thing with ear flaps which tie together under your chin, the kind of thing Sherlock Holmes would wear if he worked on a Russian trawler.
- A round thing which belongs to my girlfriend and appears to be made of leather. I don't really know how to describe it better but the important point is it's too small for me so I'd have to run with one hand held to my head to stop it blowing away.
- A motorcycle helmet.
Now, perhaps I'm being picky but none of the above really strikes me as suitable for use while huffing and puffing round the block. I may just have to wait until it gets dark and go out then.
Then again, I've always fancied being a famous detective...
Wednesday, November 28, 2007
What is Crinagen? (part two)
In addition to Crinagen, Raztec Enterprises later developed Natrecia, a herbal supplement specifically blended to combat hair loss. Natrecia can be used by men and women with minimal side effects, and is intended to be taken as a pill once daily.
A 30 day supply (1 bottle) of Crinagen costs $19.95, though it's worth buying more because the price per bottle reduces if you buy 2 or 4 bottles at a time. A 30 day supply of Natrecia is also $19.95 and there are similar advantages to buying more bottles in one go. Shipping in the US is free.
Neither Crinagen nor Natrecia is FDA approved, because like Revivogen, their exclusively natural lists of ingredients mean that they do not require such regulation. Crinagen was developed before the comparable product Revivogen appeared on the market and while it has many loyal customers, it now exists in the shadow of the latter product in terms of market share. It is possible that this has more to do with marketing than anything else though, as Dr. Razack's product web site is heavy on the science and relatively light on marketing. In fact, with it's triple action approach to inhibiting DHT production, stimulating blood flow in the scalp and suppressing immune system reactions within the follicles themselves, Crinagen combats hair loss on more levels than its newer but more slickly marketed rival. All this may be about to change however, as the Raztec Enterprises web site is currently being revamped for a relaunch in the near future.
Tuesday, November 27, 2007
What is Crinagen? (part one)
Currently an interventional neuroradiologist at the Bayfront Medical Center in Florida, Dr. Nasser Razack's approach to the problem of hair loss has always been meticulously scientific. Crinagen only contains ingredients and compounds that have been medically proven to be effective in treating hair loss, and Dr. Razack's review of the medical literature is as thorough as it gets. The basic ingredients of Crinagen have remained the same since it was first produced, though a number of new versions have been released over time. Each new version introduced minor changes to the product, but Dr. Razack is slow to make changes to the formula for Crinagen because he prefers to wait for conclusive medical evidence before deciding to include a new ingredient. The current version was released in October 2001 and is the 4th to be released.
Because it is a topical and completely natural product like Revivogen, Crinagen can be used by men and women alike and has no systemic or hormonal side effects. In addition to being a DHT inhibitor, Crinagen works to increase the flow of blood to the follicles of the scalp. It also suppresses immune system reactions that can cause inflammations of the scalp which in turn compound the damage caused to follicles by DHT. Crinagen has been proven to reduce DHT production in the scalp by up to 98%. Its ingredients not only combat hair loss, but also combine in ways that enable Crinagen to work simultaneously on a number of fronts at once. Some of its most powerful ingredients are Azelaic acid, Vitamin B6, Zinc acetate, Niacin, Saw Palmetto, Ginkgo Biloba and Proanthocyanidins from grape seed extract.
More tomorrow...
Monday, November 26, 2007
Creating a hair loss community - can you help?
Wednesday, November 21, 2007
What is Revivogen? (part two)
Beyond its virtues as a cocktail of natural DHT inhibitors, Revivogen has another advantage over pharmaceutical treatments. It doesn't stop at impeding the conversion of testosterone into DHT, it also works to prevent the process by which DHT binds to androgen receptors within the hair follicles themselves. In other words, like other treatments it reduces the amount of DHT being produced in the first place, but goes further to protect follicles from damage caused to them by contact with any DHT still present in the scalp.
The natural ingredients that Revivogen contains are Gamma Linolenic acid (GLA), Alpha Linolenic acid (ALA), Linoleic Acid, Oleic Acid, Azelaic acid, Vitamin B6, Zinc, Saw Palmetto Extract, Beta-Sitosterol and Procyanidin Oligomers. Many consumers apply it once daily, often at bedtime. The product range also includes a shampoo and a conditioner which can be used to help the hair appear fuller and thicker.
A 3 month supply of the topical solution (known as Revivogen Scalp Therapy) currently costs $89, but if you want the shampoo and conditioner to go with it, your 3 month supply will cost $119. Although the shampoo and conditioner may help your hair look thicker and healthier, the DHT inhibiting effects of Revivogen come exclusively from the topical solution, so if you want to cut costs and focus on the action at the level of your follicles you can probably dispense with the rest. You might need to use Revivogen for up to 6 months before noticing any benefits.
Revivogen can be used in combination with pharmaceutical DHT inhibitors or regrowth agents such as Finasteride (Propecia) and Minoxidil (Rogaine), and some like to use all 3 treatments as part of a hair treatment maintenance regime. If you use both Revivogen and Minoxidil it is important to use them at different times of the day so that each can work its magic without interference from the other.
The catch with Revivogen is that because it is not FDA approved or regulated there is currently no clinical data available concerning its efficacy as a treatment for hair loss.
Tuesday, November 20, 2007
What is Revivogen? (part one)
Revivogen has been on the market since 1999 and is not FDA approved. It must be remembered however that it does not require FDA approval because its active ingredients are all natural.
For many consumers, the company's branding of Revivogen as a treatment that only contains naturally occurring DHT inhibitors is one of the most attractive things about it. Moreover, it is a topical solution applied directly to the scalp, so unlike the drugs Finasteride and Dutasteride its inhibition of DHT is specific to the tissue of the scalp and does not result in systemic side effects. Like Dutasteride, Revivogen combats types I and II of the 5-alpha-reductase enzyme which is responsible for metabolising testosterone into DHT, the process that eventually contributes to hair loss in those who are genetically susceptible.
More tomorrow, but comments always welcome!
Sunday, November 18, 2007
Baldness and self esteem
I wish I could say that was because I'm a strong person with a well developed sense of self esteem and losing my hair was something I could just brush off (along with the hair on my shoulders). That wouldn't be true, however. I think it's closer to the truth to say that I just didn't have much self confidence to begin with and as a result didn't have a lot to lose. I'm still trying to work out whether or not that's a good thing.
Until tomorrow then. I'm a baldy, hear me roar!
How Dangerous is a Hair Transplant?
To my knowledge, there has been only one death from a hair transplant anywhere in North America, as previously reported. This death reflects what appears to be completely incompetent medical care. The clinic where this death occurred, known for bargain basement prices, is still performing surgery and it appears that the patients that go there do not focus on risks of death or complications from a hair transplant. One might ask those who continue to even consider this place for surgery, "Why try to save a few dollars and place your life on the line?"
Until now I'd never really considered the risks associated with hair transplantation, I guess because I hadn't really thought of it as "surgery" per se. There is a history of heart disease in my family though, so Dr. Rassman's post makes interesting reading. Is a cosmetic procedure ever worth risking your life for?
Friday, November 16, 2007
What is Finasteride/Propecia (part two)?
On the downside, possible side effects reported by a small proportion of men using Finasteride during trials have included abdominal pain, back pain, decreased libido and volume of ejaculate, impotence, dizziness, rash, swelling of the lips and face, breast tenderness and testicular pain. Problems such as these cleared up after ceasing the treatment. For many participating men who remained on Finasteride, side effects reduced or resolved during the course of their treatment. Women who are or may become pregnant should not handle Finasteride (especially crushed tablets) due to a risk that the drug may cause birth defects in a male fetus. Men using Finasteride should inform their doctor prior to taking a PSA (prostate-specific antigen) test for prostate cancer as the drug may interfere with results. The use of Finasteride is banned in many sports as its presence in the blood can mask traces of steroid abuse.
In addition to its approved FDA status, Finasteride's popularity can be attributed to the fact that it is one of the most convenient measures against hair loss on the market. Consumers will also be pleased that with the expiration of Merck's patents on Proscar and Propecia in June 2006, a range of generic Finasteride alternatives has begun to bring prices for the treatment down considerably. A three month (90 tablet) run of 5 mg doses able to be cut into quarters with a pill cutter now costs anything from $116 (generic) to $409 (branded), making the cost of a daily dose of the drug a dollar a day or lower if consumers are prepared to shop around.
Thursday, November 15, 2007
What is Finasteride/Propecia (part one)?
Available only with a doctor's prescription, Finasteride counters hair loss by chemically preventing the metabolism of testosterone into dihydrotestosterone (DHT) within the body. It achieves this by targeting and inhibiting type II 5-alpha-reductase, one of two types of an enzyme able to facilitate such a conversion. By interfering with this process Finasteride greatly reduces the amount of DHT present in, among other tissue in the body, the scalp. The detrimental effect that DHT has on the vitality of the individual follicles and hairs of susceptible individuals can thus be negated, or more accurately, deferred.
More tomorrow...
Wednesday, November 14, 2007
What are Dihydrotestosterone (DHT) Inhibitors?
Depending on your gender, stage of hair loss and other factors, your available options may include taking a daily Finasteride or Dutasteride tablet or capsule to reduce the levels of DHT circulating throughout your entire body. Or, if you don't like the idea of such "system wide" approaches, or cannot use them for other reasons, you might benefit from natural and topical solutions, lotions and creams applied directly to the scalp to combat various phases of the production of DHT and its attempts to combine with your follicles' androgen receptors.
In addition, some of these products are frequently used in combination with each other. Tomorrow I'll take a look at some of the market leading and most popular DHT inhibitors.
Tuesday, November 13, 2007
Why Hair Loss Heaven?
1. A welcoming, supportive community where people can talk about their experience of hair loss without fear of ridicule.
AND
2. A resource people can use to find impartial, accurate information about hair loss and all the various hair preservation and restoration options.
From my own experiences of searching the Internet for helpful hair loss resources I know there are a lot of places which certainly don't fulfill those criteria and I guess that was the driving factor behind my initial motivation. I hope that if you're reading this you'll want to join me and help build our community - why not register at the site and say hello in the forums? You'll be made very welcome!
Monday, November 12, 2007
The 5 best things about being bald
5. Losing a comb is no big deal. If you still have a little at the back and on the sides, a toothbrush will suffice.
4. Having hair on your back actually becomes a source of pride: "Whoah, look at them thick roots!"
3. If you injure your head and need stitches, you look about as hard as it's possible for any human being to look.
2. People will automatically credit you with wisdom and maturity beyond your years. This is great until you encounter a situation which actually calls for wisdom and maturity.
And, at number one:
1. You never have to worry about losing your hair.
Sunday, November 11, 2007
The Women’s Hair Loss Project
Saturday, November 10, 2007
Bloody hell, it's chilly!
Of course, on the bright side, we now have a good excuse to wear a hat! What a great device hats are, they keep us warm and (personally speaking, at least) improve our looks at the same time...
Maybe this time of year's not so bad after all.
Monday, May 07, 2007
In the footsteps of phantoms
My only question is: Will this be a sustainable solution, or will he go down the Michael Jackson top-up procedure every other day route that leads to freakdom? Has this ghostrider embarked on a journey of folly that will provide the rest of us with unfounded hope, or is this a real breakthrough? Ok fine, it's two questions - but you get the picture: he's blazing a trail. But where that leads is just about anybody's guess.
Friday, April 27, 2007
Fateful Interventions
Back to my friend, after a while things started getting better for him - he managed to sort out his personal issues, found a new job and things were beginning to look generally better and brighter for him. And here's the thing: after about a month or so of getting his life back on track, he noticed that his hair had started thickening again. And if it hadn't seen it for myself I truly wouldn't have believed it. But there it is: incontrovertible proof (albeit of the anecdotal variety) that stress can lead to hairloss. A pointed reminder not to put dealing with things off... lest the Fates decide to start pulling things out.
Thursday, April 26, 2007
Who’s afraid of the big bad baldie?
Friday, April 20, 2007
Collective Blindness
Wednesday, April 18, 2007
Mind the gap
Monday, April 16, 2007
The baldness of a head begins at the temples
Inkqayi ingena ngenlontlo
for which the literal translation is "The baldness of a head begins at the temples."
This proverb that expresses the idea that big things may result from a seemingly small matter is usually said in defense of small beginnings, and it's roughly the equivalent of the English proverb "The journey of a thousand miles begins with a single step." It's refreshing to see a different cultural take on hair loss that links the negative onset of baldness with a greater positive change. So the next time you suggest a great idea to your boss and they say it will take too long to implement, go ahead and tell them: "The baldness of a head begins at the temples". Inkqayi ingena ngenlontlo. Baby steps...
Monday, April 09, 2007
Massaging proteins
Thursday, April 05, 2007
Time to Smile
Thursday, February 15, 2007
Crudoleum and hair loss
Wednesday, February 14, 2007
Chicken Rub
HAIR LOSS: Those suffering from hair loss or baldness, may apply a paste of hot olive oil, one tablespoon of honey, one teaspoon of cinnamon powder before bath and keep it for approx. 15 min. and then wash the hair. It was found to be effective even if kept on for 5 minutes.
Now we all know that olive oil, honey and even cinnamon have proven medicinal properties, but you’ll forgive me if I think this particular paste will do better spending 15 minutes on this evening’s chicken than on my head.
Saturday, February 10, 2007
RoboCure for baldness
Thursday, February 08, 2007
Dodgy Head Space
Thursday, February 01, 2007
Steve Wilkos makes the Bald List
The fact is that you've all probably seen Steve Wilkos before - on The Jerry Springer Show - keeping feuding lovers/families/family-lovers apart while the audience chants his name over and over again in primeval ecstasy: "Steve! Steve! Steve!" Now that we're all up to speed, what I want to know is: how desperate are we for role models that this particular bald-headed goon made the List? He sure is bald but that's where his eligibility to be a bald role model ends. If we're so desperate for role models, we should try being our own role models for a change. Or better yet: we should try being somebody else's.
Wednesday, January 24, 2007
The best a man can get
Monday, January 22, 2007
The Three Phases
Friday, January 19, 2007
B*ld-faced lie
Thursday, January 18, 2007
Scale of Dread
- It makes no reference at all to the denial experienced in stage 2, as in: “Oh my God, this isn’t happening to me.”
- It completely ignores the anger experienced in Stage 3, as in: “What the %^%@ are you looking at?”
- It neglects to mention the desperate bargaining experienced in Stage 4 as in: “Dear God, you know I’ve never asked you for anything before…”
- It totally skips the depression that sets in by Stage 5, as in: “Stuff like this always happens to me.”
- And it cannot begin to summarise the bitter acceptance of Stages 6 & 7, as in: “I suppose it’s not the end of the world.”
Solution to overcome the Scale of Dread: print it out and colour it in using brightly coloured crayons - do not bother trying to colour within the lines. Now paste it on your wall and smile as your remind yourself that while in some cases hair loss may be inevitable, in all cases the way you deal with it is not.
Wednesday, January 17, 2007
Bald on the 11th of July
Thursday, January 11, 2007
43things.com
One person's stated goal is to find other people with Alopecia Universalis and there have indeed been some awesome responses to his call for Alopecians to unite - particularly from women. The most recent blog is from a 15 year-old girl struggling particularly because of her age to deal with hair loss. Her brave blog reminded me just how acutely image-conscious kids of a school-going age can be, and how difficult it is to fit in at the best of times. Though I recognise that we may not have a cure for her Alopecia, there is however a cure for her feelings of loneliness. So go ahead, log in, and give the girl a cheer.
Tuesday, January 02, 2007
New guide to DHT Inhibitors published at Hair Loss Heaven
Monday, January 01, 2007
Happy New Year!
2007 figures to be a big year for Hair Loss Heaven - we hope you'll join us.
Best wishes,
Mac